Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 18, Issue 30, Pages 5918-5926Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob01160f
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Funding
- National Natural Science Foundation of China [NSFC-21572178, NSFC-21971206]
- Education Department of Shaanxi Provincial Government [17JK0732]
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We report herein an efficient, economical, and scalable trifluoromethylthiolation of aldehydes to generate trifluoromethylthioestersviaa visible light-promoted radical process. The transformation features cheap reagents, simple operation, a broad substrate scope, and especially no metal involved in the reaction. Trifluoromethylthiolations of several complex aldehyde-containing bioactive compounds have been realized; thus the approach has the potential to be an important tool for the late-stage functionalization of advanced synthetic intermediates and bioactive molecules, and should have many applications in medicinal chemistry.
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