Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 8, Issue 30, Pages 6357-6365Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb00980f
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Funding
- Swiss National Science Foundation [200020_172619, IZPIP0_177995]
- Adolphe Merkle Foundation
- US National Science Foundation [OISE 1844463]
- Department of Veterans Affairs Rehabilitation Research and Development Service Merit Review Awards [1264735, 12418820]
- Research Career Scientist Award [12635707]
- Advanced Platform Technology Center [I50 RX001871]
- Swiss National Science Foundation (SNF) [IZPIP0_177995, 200020_172619] Funding Source: Swiss National Science Foundation (SNF)
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Neural implants that are based on mechanically adaptive polymers (MAPs) and soften upon insertion into the body have previously been demonstrated to elicit a reduced chronic tissue response than more rigid devices fabricated from silicon or metals, but their processability has been limited. Here we report a negative photoresist approach towards physiologically responsive MAPs. We exploited this framework to create cross-linked terpolymers of 2-hydroxyethyl methacrylate, 2-hydroxyethyl acrylate and 2-ethylhexyl methacrylate by photolithographic processes. Our systematic investigation of this platform afforded an optimized composition that exhibits a storage modulus E' of 1.8 GPa in the dry state. Upon exposure to simulated physiological conditions the material swells slightly (21% w/w) leading to a reduction of E' to 2 MPa. The large modulus change is mainly caused by plasticization, which shifts the glass transition from above to below 37 degrees C. Single shank probes fabricated by photolithography could readily be implanted into a brain-mimicking gel without buckling and viability studies with microglial cells show that the materials display excellent biocompatibility.
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