Journal
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY
Volume 15, Issue 3, Pages 243-249Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/ACI.0000000000000157
Keywords
commensal bacteria; epithelial barrier; food allergy; gut microbiota; probiotics; short-chain fatty acids
Categories
Funding
- NIAID [AI106302]
- Food Allergy Research and Education (FARE)
- UChicago Digestive Diseases Center Core Grant [P30DK42086]
- Italian Ministry of Health [PE-2011-02348447]
- US Dept. of Energy [DE-AC02-06CH11357.NS]
Ask authors/readers for more resources
Purpose of review We review the evidence that environmental stimuli that perturb naturally selected host-microbe interactions are driving the increasing prevalence of food allergy and examine the mechanisms by which commensal bacteria regulate tolerance to dietary allergens. Recent findings Antibiotic use and the consumption of a high-fat/low-fiber diet have a major and rapid impact on gut bacterial populations, with long-term consequences for both overall microbial community structure and the regulation of host immunity. Recent work emphasizes the role of mucosa-associated commensal bacteria in eliciting a barrier-protective response critical to preventing allergic sensitization to food. Murine model studies are informing the development of novel live biotherapeutic approaches as an adjunctive therapy to enhance antigen-specific oral desensitization and to promote lasting tolerance in patients with food allergy. Summary Strategies based on modulating the composition and/or functionality of the gut microbiome hold promise for the treatment of food allergy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available