Journal
BLOOD RESEARCH
Volume 55, Issue -, Pages 63-71Publisher
KOREAN SOC HEMATOLOGY
DOI: 10.5045/br.2020.S011
Keywords
Extranodal natural killer/T cell lymphoma; ENKTL; Non-Hodgkin's lymphoma; Immunotherapy
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Extranodal natural killer (NK)/T cell lymphoma (ENKTL) is a distinct subtype of Non-Hodgkin's lymphoma mainly involving the nasal area. Since the entity was first recognized, treatment strategies have been evolving from anthracycline-based chemotherapy and radiotherapy to L-asparaginase containing regimens and recently immune checkpoint inhibitors. With the currently used combined chemotherapy and radiotherapy, more than 70% of patients with localized disease can be cured. L-asparaginase containing regimens have significantly improved treatment outcomes among patients with advanced disease. However, the treatment outcomes of patients with disease refractory to L-asparaginase containing regimens or who experience recurrence remain poor. In this article, we cover the current treatments for ENKTL and emerging treatment approaches.
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