Journal
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
Volume 22, Issue 3, Pages 413-420Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s10147-017-1104-3
Keywords
MicroRNA; Long non-coding RNA; Extracellular vesicle; Cancer; Liquid biopsy
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Funding
- 'Development of Diagnostic Technology for Detection of miRNA in Body Fluids'
- Japan Agency for Medical Research and Development and New Energy and Industrial Technology Development Organization
- Grants-in-Aid for Scientific Research [17K09471] Funding Source: KAKEN
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Circulating non-coding RNAs, including microRNAs and long non-coding RNAs, and the protein components of extracellular vesicles are promising biomarkers for the non-invasive detection of cancer at an early stage. This systematic review discusses the increasing number of well-designed cancer biomarker-related studies that have been published worldwide. In many of these studies, high diagnostic accuracy, which is represented as the area under the receiver operating characteristic curve being >0.8, could be achieved using combinations of circulating microRNAs. In addition, similar diagnostic accuracies were reported using long non-coding RNAs or proteins present in extracellular vesicles, although these evidences were based on a limited number of studies.
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