Journal
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
Volume 24, Issue 15, Pages 8160-8163Publisher
VERDUCI PUBLISHER
DOI: 10.26355/eurrev_202008_22503
Keywords
Finasteride; Spermatogenesis; Dihydrotestosterone; 5 alpha-reductase; Gene
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OBJECTIVE: In this study, the impact of Finasteride was assessed on the expression of four biomarkers of the spermatogenesis process, namely Dazl, Tsga10, Sycp3, and Prm2 using the Real -Time PCR technique. MATERIALS AND METHODS: The experimental protocol was carried out on male NMRI mice for 35 days in which three animal groups received three different doses of Finasteride (1, 5, and 20 mg/body weight). RESULTS: The results showed that the expression levels of both Dazi and Prm2 genes were significantly decreased only at a dose of 20 mg/body weight, but at doses of 5 and 20 mg/body weight, the expression levels of Sycp3 and Tsga10 genes were significantly reduced. CONCLUSIONS: It seems that Finasteride, at a dose of 5 mg/body weight or higher, may have adverse effects on male spermatogenesis and fertility.
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