4.7 Review

An overview of polyamine metabolism in pancreatic ductal adenocarcinoma

Journal

INTERNATIONAL JOURNAL OF CANCER
Volume 142, Issue 10, Pages 1968-1976

Publisher

WILEY
DOI: 10.1002/ijc.31155

Keywords

polyamines; pancreatic ductal adenocarcinoma; polyamine transport; metabolism

Categories

Funding

  1. Department of Defense Peer Reviewed Cancer Research Program [CA110724, W81XWH-12-1-0433]

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Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest major cancers, with a five year survival rate of less than 8%. With current therapies only giving rise to modest life extension, new approaches are desperately needed. Even though targeting polyamine metabolism is a proven anticancer strategy, there are no reports, which thoroughly survey the literature describing the role of polyamine biosynthesis and transport in PDAC. This review seeks to fill this void by describing what is currently known about polyamine metabolism in PDAC and identifies new targets and opportunities to treat this disease. Due to the pleiotropic effects that polyamines play in cells, this review covers diverse areas ranging from polyamine metabolism (biosynthesis, catabolism and transport), as well as the potential role of polyamines in desmoplasia, autophagy and immune privilege. Understanding these diverse roles provides the opportunity to design new therapies to treat this deadly cancer via polyamine depletion.

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