Journal
CURRENT MOLECULAR MEDICINE
Volume 15, Issue 9, Pages 861-866Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1566524015666151026100042
Keywords
Cell-in-cell; entosis; entotic cell death; cannibalism; phagocytosis; engulfment; autophagy; LAP; cell competition
Categories
Funding
- NCI [RO1CA154649]
- Cancer Research UK [C47718/A16337]
- Cancer Research UK [16337] Funding Source: researchfish
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Entosis is a cell-in-cell formation mechanism that targets viable cells for uptake in epithelial cell cultures and human tumors. Entotic cells control their own engulfment, by invading into their hosts in a Rho-GTPase and actomyosin-dependent manner. Although entotic cells are internalized while alive, most eventually undergo a non-apoptotic form of cell death, called entotic cell death, that is executed non-cell-autonomously by autophagy proteins and lysosomes. Here we review the current understanding of entosis and entotic cell death and discuss the potential roles of this process in cancer.
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