Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 13, Issue 2, Pages 198-208Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.17240
Keywords
PARP; PARP inhibitor; drug resistance; DNA repair
Categories
Funding
- China-Kazakhstan collaboration grant [CK-07-09]
- National Natural Science Foundation of China [81272901]
- Department of Biology, SST, and Nazarbayev University
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One of the DNA repair machineries is activated by Poly ( ADP- ribose) Polymerase ( PARP) enzyme. Particularly, this enzyme is involved in repair of damages to single- strand DNA, thus decreasing the chances of generating double- strand breaks in the genome. Therefore, the concept to block PARP enzymes by PARP inhibitor ( PARPi) was appreciated in cancer treatment. PARPi has been designed and tested for many years and became a potential supplement for the conventional chemotherapy. However, increasing evidence indicates the appearance of the resistance to this treatment. Specifically, cancer cells may acquire new mutations or events that overcome the positive effect of these drugs. This paper describes several molecular mechanisms of PARPi resistance which were reported most recently, and summarizes some strategies to reverse this type of drug resistance.
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