Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 102, Issue -, Pages 1257-1265Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2017.05.030
Keywords
Chitosan; Thymol; T-C@AgNPs
Funding
- Department of Biotechnology (DBT), Ministry of Science and Technology, Government of India, New Delhi, India [BT/PR10338/PFN/20/922/2013]
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The advent of biodegradable polymer-encapsulated drug nanoparticles has made an exciting area of drug delivery research. The present study investigated novel and simple route for synthesis of thymol loaded chitosan silver nanoparticles (T-C@AgNPs) using chitosan and thymol as reducing, capping agent respectively to understand the therapeutic efficacy. The UV-vis spectroscopy, DLS, FT-IR, SEM, EDS, XRD used for characterization and radical scavenging activity, anti-microbial and biocompatibility was taken to ascertain an efficacy of novel T-C@AgNPs. The T-C@AgNPs intense peak at 490 nm indicates the formation of nanoparticles and had average particle size of 28.94 nm with spherical shape, monodisperse state in water, also exhibited excellent biocompatibility of cubic shaped pure silver element containing T-C@AgNPs. The antibacterial activity was studied for gram positive and gram negative food-borne pathogens and effective inhibition at 100 mu g mL(-1) to S. aureus, S. epidermidis, S. haemolyticus (10.08,10.00, 11.23 mm) and S. typhimurium, P. aeruginosa and S. flexneri (9.28, 9.33,12.03 mm) compared to antibiotic Streptomycin. This study revealed the efficacy against multiple food-borne pathogens and therapeutic efficacy of T-C@AgNPs offers a valuable contribution in the area of nanotechnology. This proved to be a first-class novel antimicrobial material for the first time in this study. (C) 2017 Elsevier B.V. All rights reserved.
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