Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 98, Issue -, Pages 550-556Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.01.121
Keywords
Chitosan; Gentamicin; Film; Antibacterial property
Funding
- National Science Foundation of China [11532003, 51273072]
- Project of Natural Science Research of Higher Education Institutions of Jiangsu Province [15KJ13310001]
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Gentamicin modified chitosan film (CS-GT) was produced using a three-step procedure comprising: (i) the chitosan solution was air-dried to form a chitosan (CS) film, (ii) using citric acid to generate the amide and carboxyl groups on the surface of CS, (iii) the CS with surface carboxyl groups was modified by grafting of gentamicin. After modification, this CS-GT film has excellent hydrophilicity and biocompatibility. It is very evident that the gentamicin grafting treatment significantly improves the antibacterial properties of the CS film. Our preliminary results suggest that this novel gentamicin modified chitosan film, which can be prepared in large quantities and at low cost, should have potential application in biomedical applications. (C) 2017 Elsevier B.V. All rights reserved.
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