Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 103, Issue -, Pages 941-947Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2017.05.132
Keywords
Ocular drug delivery; Nanostructured lipid carriers; Quaternized chitosan; Thermosensitive hydrogel; Sustained release
Funding
- Liaoning Institute of Science and Technology [Yd201609]
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This study aims to explore a novel composite thermosensitive in situ gelling formulation which the nanostructured lipid carriers (NLC) was incorporated into hydroxypropyltrimethyl ammonium chloride chitosan (HACC)-based hydrogels, and the resulting formulation investigated for its potential to act as a potential sustained ocular delivery system. NLC formulation loaded with dexamethasone (DXM) were prepared using the melt-emulsification method. The particle size, zeta potential, encapsulation efficiency, and morphological properties of the NLC were characterized. The HACC was synthesized and structure was analyzed by FT-IR and H-1 NMR. A thermosensitive hydrogel was designed and prepared by simply mixing HACC and beta-glycerophosphate (beta-GP). The obtained formulation showed a rapid solution-to-gel transition at 35 degrees C. The NLC were then incorporated in HACC/beta-GP hydrogel to form a NLC-loaded hydrogel carrier. In vitro release studies, 88.65% of total DXM was released from the NLC-HACC/GP gel within 3 days, indicating DXM-based NLC-gel could release drug sustainably. Taken together, DXM-based NLC-HACC/GP gel is a promising drug delivery system. (C) 2017 Elsevier B.V. All rights reserved.
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