Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 102, Issue -, Pages 60-67Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.03.083
Keywords
Mori Fructus polysaccharides; Hepatoprotective activity; Characterizations
Funding
- National Natural Science Foundation of China [31570358]
- Guizhou Province High Level Creative Talents Cultivation [[2015]4033]
- Guizhou Province Special Found for Modern Science and Technology Industrial of Traditional Chinese medicine research and development [[2013]5005]
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Crude polysaccharides of Mori Fructus (MFPs) were found to have anti-inflammatory antioxidant, and immuno-enhancing activities. However, the structure of the polysaccharides was ambiguous and its holistic hepatic protection evaluation was defective. This study was conducted to illustrate the characterization of MFPs, and evaluate its hepatoprotective activities. The results found that MFPs contained 67.93 +/- 1.18% carbohydrates, 31.03 +/- 0.54% uronic acid, and little protein and sulfate. The average molecular weight was ranging from 112.2 kDa to 181.9 kDa. Monosaccharide component analysis indicated that MFPs was mainly composed of glucose, galacturonic acid, rhamnose and galactose. Both the acute and subacute alcoholic-induced liver injury animal models were adopted to evaluate the MFPs's hepatoprotective activity. After administration of MFPs, both serological indexes (aspartate aminotransferase and alanine aminotransferase) and hepatic indicators (glutathione, superoxide dismutase, glutathione peroxidase and malondialdehyde) were improved by comparing with the non-MFPs group. The hepatic histopathology results also showed a prominent lipid degeneration and microvesicular steatosis attenuation in the MFPs groups. These outstanding hepatic protecting activities of MFPs might be related to its activation of ethanol dehydrogenase, elimination of free radicals and/or inhibition of lipid peroxidation capacities. MFPs could be important active substances for preventing and remedying liver injury. (C) 2017 Published by Elsevier B.V.
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