Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 95, Issue -, Pages 962-973Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2016.10.085
Keywords
Poly (vinyl alcohol); Sodium alginate; Cellulose nanocrystals; Crosslinking; Freeze drying; Tissue engineering
Funding
- Yeungnam University
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Cellulose nanocrystals reinforced poly (vinyl alcohol)/sodium alginate hybrid scaffolds were fabricated by using freeze casting and freeze drying method. In this study, the effect of crosslinking agents such as calcium chloride, orthophosphoric acid, and borax on morphological, structural, thermal, mechanical, and cytocompatibility (cell adhesion and proliferation) properties was investigated. The results showed that the change in type of crosslinking agent significantly changed the properties of the hybrid scaffolds. Based on this study, borax-crosslinked hybrid scaffold showed good fibrous porous structure with high porosity (95.2%), highest water uptake capacity, good thermal stability, mechanical stability (storage modulus), and in vitro cell adhesion and proliferation with fibroblast (NIH3T3) cells. This primarily research study explores the way for further use of this crosslinking agent to design and fabricate scaffolds for tissue engineering applications. (C) 2016 Elsevier B.V. All rights reserved.
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