Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 105, Issue -, Pages 204-212Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2017.07.026
Keywords
Anti-complementary activity; Immunological activity; jujube lignin
Funding
- Foundation of Fuli Institute of Food Science, Zhejiang University [KY201404]
Ask authors/readers for more resources
Two homogenous biological macromolecules, designated as JJC1 and JJC2 were extracted from Zizyphus jujube cv. Jinchangzao. Their molecular weights were determined to be 56.03 and 112.11 kDa by high performance gel permeation chromatography (HPGPC), respectively. Chemical and spectral analysis indicated that both JJC1 and JJC2 mainly consisted of lignin, along with carbohydrates (similar to 18%). Both JJC1 and JJC2 could stimulate the proliferation of spleen lymphocytes, and enhance phagocytosis and NO production of RAW264.7 cells. In addition, JJC2, but not JJC1 elicited an inhibitory effect on complement activation through the classical pathway (CH50: 2.73 mg/mL) as well as the alternative pathway (AP(50): 2.99 mg/mL). These findings implied that water-soluble lignins were one of the bioactive components in Z. jujube, and further provided insights into the understanding of molecular basis for diverse medicinal and nutritional values of this fruit. (C) 2017 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available