Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 95, Issue -, Pages 643-649Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2016.11.098
Keywords
Cytotoxicity; 5-Fluorouracil; Nanoparticles
Funding
- National Plan for Science, Technology and Innovation (MAAREFAH), King Abdulaziz City for Science and Technology, Kingdom Saudi Arabia [11-NAN1461-02]
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5-Fluorouracil (5-FU) loaded chitosan (C) coated polylactic-co-glycolic acid (PLCA) nanoparticles [NPs] (C-5-FU PLGANPs) and polycaprolactone [PCL] (C-5-FU PCL NPs) were employed as the carriers for cancer treatment. The prepared NPs showed the spherical shape of NPs with the particle size in the range of 188.1-302.2 nm with polydispersity index (PDI) of <0.30. C-coated NPs converted zeta potential from negative to positive value with small modification in particle size distribution. The entrapment efficiency of 5-FU was recorded in the range of 32-51%. The in vitro release studies showed an initial rapid 5-FU release followed by a sustained release profile. The in vitro cytotoxicity of C-5-FU PLGA NPs showed significant inhibition of colon cancer cells (HT-29) compared to the other NPs and drug solution. These results showed that C-5-FU PLGA NPs can be considered as a promising carrier for cancer therapy. (C) 2016 Elsevier B.V. All rights reserved.
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