Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 97, Issue -, Pages 115-122Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2016.12.090
Keywords
Chitosan; Nanoparticles; Nanocarboplatin; Carboplatin; Anticancer
Funding
- Department of Science and Technology (SERB), New Delhi (India) [SB/YS/LS-296/2013]
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Aim of the studies to synthesized chitosan nanoparticles by an ionic interaction procedure. The nanoparticles were characterized by physicochemical Methods like, DLS, TEM, Surface potential measurements, FT-IR and DSC. The average particle size of chitosan and carboplatin nanoparticles was found to be 277.25 +/- 11.37 nm and 289.30 +/- 8.15 nm and zeta potential was found to be 31 +/- 3.14 mV and 33 +/- 2.15 mV respectively with low polydispersity index. The maximum entrapment of carboplatin in nanoparticles was a spherical shape with a positive charge. The maximum encapsulation and loading efficiencies of carboplatin (5 mg/ml) were obtained to be 58.43% and 13.27% respectively. The nanocarboplatin was better blood compatibility as compared to chitosan nanoparticles. Finally, the cytotoxic effects of the carboplatin loaded chitosan nanoparticles were tested in-vitro against breast cancer (MCF-7) cell lines. Our studies showed that the chitosan nanoparticles could be used as a promising candidate for drug delivery for the therapeutic treatment of breast cancer. (C) 2017 Elsevier B.V. All rights reserved.
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