Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 95, Issue -, Pages 1153-1158Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2016.11.005
Keywords
High concentration; High density; Aggregation; Chromatography; Ultrafiltration
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Local transient high protein concentration or high density condition can occur during processing of protein solutions. Typical examples are saturated binding of proteins during column chromatography and high protein concentration on the semi-permeable membrane during ultrafiltration. Both column chromatography and ultrafiltration are fundamental technologies, specially for production of pharmaceutical proteins. We summarize here our experiences related to such high concentration conditions. (C) 2016 Elsevier B.V. All rights reserved.
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