Journal
CURRENT MICROBIOLOGY
Volume 71, Issue 1, Pages 121-128Publisher
SPRINGER
DOI: 10.1007/s00284-015-0838-2
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Funding
- National Natural Science Foundation [81371851, 81071316, 81271882]
- New Century Excellent Talents in Universities [NCET-11-0703]
- National Megaprojects for Key Infectious Diseases [2008ZX10003-006]
- Excellent PhD thesis fellowship of southwest university [kb2009010, ky2011003]
- Fundamental Research Funds for the Central Universities [XDJK2012D011, XDJK2013D003]
- Natural Science Foundation Project of CQ CSTC [CSTC, 2010BB5002]
- Chongqing Municipal Committee of Education [YJG123104]
- Undergraduates Teaching Reform program [2011JY052]
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NarGHJI operon encodes a nitrate reductase that can reduce nitrate to nitrite. This process enhances bacterial survival by nitrate respiration under anaerobic conditions. NarGHJI operon exists in many bacteria, especially saprophytic bacteria living in soil which play a key role in the nitrogen cycle. Most actinomycetes, including Mycobacterium tuberculosis, possess NarGHJI operons. M. tuberculosis is a facultative intracellular pathogen that expands in macrophages and has the ability to persist in a non-replicative form in granuloma lifelong. Nitrogen and nitrogen compounds play crucial roles in the struggle between M. tuberculosis and host. M. tuberculosis can use nitrate as a final electron acceptor under anaerobic conditions to enhance its survival. In this article, we reviewed the mechanisms regulating nitrate reductase expression and affecting its activity. Potential genes involved in regulating the nitrate reductase expression in M. tuberculosis were identified. The conserved NarG might be an alternative mycobacterium taxonomic marker.
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