Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 93, Issue -, Pages 52-61Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2017.10.015
Keywords
Gut bacteria; Polyamines; Polyamine transport; Polyamine biosynthesis; Symbiosis
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Funding
- Institute for Fermentation (Osaka, Japan) [K-25-04]
- JSPS KAKENHI [17H05026]
- Grants-in-Aid for Scientific Research [17H05026] Funding Source: KAKEN
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Recent studies have reported that polyamines in the colonic lumen might affect animal health and these poly-amines are thought to be produced by gut bacteria. In the present study, we measured the concentrations of three polyamines (putrescine, spermidine, and spermine) in cells and culture supernatants of 32 dominant human gut bacterial species in their growing and stationary phases. Combining polyamine concentration analysis in culture supernatant and cells with available genomic information showed that novel polyamine biosynthetic proteins and transporters were present in dominant human gut bacteria. Based on these findings, we suggested strategies for optimizing polyamine concentrations in the human colonic lumen via regulation of genes responsible for polyamine biosynthesis and transport in the dominant human gut bacteria.
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