Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 85, Issue -, Pages 85-90Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2017.01.015
Keywords
Peroxisome-like organelle; Glycosome; Glycolysis and gluconeogenesis; Purine and pyrimidine biosynthesis; ATP/ADP and NAD/NADH glycosomal balances
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Funding
- Centre National de la Recherche Scientifique (CNRS)
- Universite de Bordeaux
- Agence Nationale de la Recherche (ANR) through the GLY-CONOV grant of the Generique call [ANR-15-CE15-0025-01]
- Laboratoire d'Excellence (LabEx) ParaFrap [ANR-11-LABX-0024]
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Peroxisomes are single-membrane cellular organelles, present in most eukaryotic cells and organisms from human to yeast, fulfilling essential metabolic functions in lipid metabolism, free radical detoxification, differentiation, development, morphogenesis, etc. Interestingly, the protozoan parasite species Trypanosoma contains peroxisome-like organelles named glycosomes, which lack hallmark peroxisomal pathways and enzymes, such as catalase. Glycosomes are the only peroxisome-like organelles containing most enzymatic steps of the glycolytic pathway as well as enzymes of pyrimidine biosynthesis, purine salvage and biosynthesis of nucleotide sugars. We-present here an overview of the glycosomal metabolic peculiarities together with the current view of the raison d'etre of this unique metabolic peroxisomal sequestration. (C) 2017 Elsevier Ltd. All rights reserved.
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