4.6 Article

Nickel/briphos-catalyzed transamidation of unactivated tertiary amides

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 18, Issue 31, Pages 6053-6057

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob01271h

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Funding

  1. National Research Foundation of Korea (NRF) - Korea government [NRF-2012M3A7B4049655, 2020R1A2C2013420]
  2. National Research Foundation of Korea [2020R1A2C2013420] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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The transamidation of tertiary amides was achievedvianickel catalysis in combination with briphos ligands.N-Methyl-N-phenylbenzamide derivatives reacted with primary amines in the presence of NiCl2/briphos L4 to provide the transamidated products in moderate to good yields. Primary aromatic amines delivered higher product yields than aliphatic amines.

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