Journal
BIOMATERIALS SCIENCE
Volume 8, Issue 16, Pages 4426-4437Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0bm00898b
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Funding
- Beijing Natural Science Foundation [7192027]
- National Natural Science Foundation of China [51973021, 51932002]
- Beijing Municipal Health Commission [BMHC-2019-9, BMHC-2018-4, PXM2020_026275_000002]
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Numerous studies have reported that hydroxyapatite nanoparticles (nano-HAPs) can inhibit the proliferation of a variety of tumor cells and this effect is different in different carcinoma cells. However, the effect of nano-HAPs on osteosarcoma cell proliferation has not been well understood thus far. In this study, we first showed that our synthesized nano-HAPs reduced cell viability and inhibited migration and invasion of OS-732 cells in a concentration-dependent manner. Using a BALB/c nude mouse tumor model, we demonstrated that nano-HAPs could effectively suppress tumor growthin vivo. We also performed RNA-seq analysis to investigate the underlying mechanism of these effects and discovered that treatment of OS-732 cells with nano-HAPs significantly downregulated the FAK/PI3K/Akt signaling pathway. Collectively, our study suggests that treatment with nano-HAPs can inhibit osteosarcoma cell growth, migration and invasionin vitroand suppress osteosarcomain vivo.
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