Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 18, Issue 31, Pages 6018-6041Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob01261k
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Thiazolones as a class of five-membered heterocyclic compounds containing both nitrogen and sulfur, have been proved to possess important biological activities. Because thiazolone molecules have many reaction sites, they can carry out a series of modification reactions, which makes them good reaction substrates for various molecular syntheses. In recent years, research on the use of asymmetric organocatalysis to construct thiazolone derivatives has attracted a lot of attention. Among these, some breakthrough results have been achieved in the asymmetric synthesis of thiazolone derivatives. This review highlights recent developments in thiazolone derivatives in asymmetric reactions, including Michael additions, Mannich reactions as well as various cascade reactions.
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