Journal
NEW JOURNAL OF CHEMISTRY
Volume 44, Issue 31, Pages 13344-13349Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9nj06339k
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Funding
- National Natural Science Foundation of China [41771342, 31872889]
- Natural Science Foundation of Shandong Province, China [ZR2019MD025]
- Key R&D Program of Shandong Province, China [2018YYSP029]
- 13th Five-Year National Key R&D Program of China [2017YFD0801504]
- Funds of Shandong Double Tops Program, China [SYL2017XTTD01]
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In this work, glucose oxidase and Au nanoclusters co-encapsulated in zeolitic imidazolate frameworks (GOx & AuNCs@ZIF-8) were obtained by simply mixing Zn2+, dimethylimidazole, glucose oxidase (GOx) and Au nanoclusters (AuNCs) at room temperature. The GOx & AuNCs@ZIF-8 composite can be used as a sensitive colorimetric sensor for glucose based on the following cascade reaction: GOx converts glucose to gluconic acid and generates H2O2, which acts as a substrate for AuNCs oxidizing 3,3 ',5,5 '-tetramethylbenzidine (TMB) to form oxidized TMB (oxTMB) detectable at 652 nm. Owing to the effective cascade reaction and protective effect of the ZIF-8 shell on enzymes, the catalytic activity of GOx & AuNCs@ZIF-8 was enhanced 19.3-fold compared with the free GOx/AuNC solution, and the glucose sensor showed high selectivity and sensitivity. Furthermore, the GOx & AuNCs@ZIF-8 composite showed high long-term storage stability and stability against digesting enzymes and chelating compounds due to the shielding effect of the ZIF-8 scaffold.
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