Journal
RESPIRATORY RESEARCH
Volume 21, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12931-020-01479-w
Keywords
SARS-CoV; MERS-CoV; SARS-CoV-2; Illness; Biological features; Clinical characteristics
Categories
Funding
- Research Project of Science and Technology Department of Fujian Province, China [2018 J01288]
- Youth Research Project of Health and Family Planning Commission of Fujian Province, China [2018-1-62, 2018-2-23]
- Quanzhou Science and Technology Project [2018 N012]
- Research Project of Collaborative Innovation Center for Maternal and Infant Health Service Application Technology [XJM1802]
- National Key Research and Development Program of China [2016YFC1304]
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Within two decades, there have emerged three highly pathogenic and deadly human coronaviruses, namely SARS-CoV, MERS-CoV and SARS-CoV-2. The economic burden and health threats caused by these coronaviruses are extremely dreadful and getting more serious as the increasing number of global infections and attributed deaths of SARS-CoV-2 and MERS-CoV. Unfortunately, specific medical countermeasures for these hCoVs remain absent. Moreover, the fast spread of misinformation about the ongoing SARS-CoV-2 pandemic uniquely places the virus alongside an annoying infodemic and causes unnecessary worldwide panic. SARS-CoV-2 shares many similarities with SARS-CoV and MERS-CoV, certainly, obvious differences exist as well. Lessons learnt from SARS-CoV and MERS-CoV, timely updated information of SARS-CoV-2 and MERS-CoV, and summarized specific knowledge of these hCoVs are extremely invaluable for effectively and efficiently contain the outbreak of SARS-CoV-2 and MERS-CoV. By gaining a deeper understanding of hCoVs and the illnesses caused by them, we can bridge knowledge gaps, provide cultural weapons for fighting and controling the spread of MERS-CoV and SARS-CoV-2, and prepare effective and robust defense lines against hCoVs that may emerge or reemerge in the future. To this end, the state-of-the-art knowledge and comparing the biological features of these lethal hCoVs and the clinical characteristics of illnesses caused by them are systematically summarized in the review.
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