Journal
CURRENT MEDICINAL CHEMISTRY
Volume 22, Issue 13, Pages 1589-1602Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867322666150209152259
Keywords
Drug delivery systems; lipid drug conjugates (LDC); nanomedicine; nanostructured lipid carriers (NLC); ophthalmology; solid lipid nanoparticles (SLN)
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The peculiar physio-anatomical structure of the eye and the poor physico-chemical properties of many drug molecules are often responsible for the inefficient treatment of ocular diseases by conventional dosage forms, and justify the development of innovative ocular drug delivery systems. Lipid-based nanocarriers (LNC) are among the newer and interesting colloidal drug delivery systems; they show the capability to improve the local bioavailability of drugs administered by various ocular routes and, therefore, their therapeutic efficacy. Furthermore, their extreme biodegradability and biocompatible chemical nature have secured them the title of 'nanosafe carriers.' This review treats the main features of LNC [namely, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and lipid-drug conjugates (LDC)]; examples and advantages of the application of these colloidal carrier systems for the ophthalmic administration of drugs are presented.
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