Journal
CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 45, Issue 2, Pages 214-217Publisher
TERMEDIA PUBLISHING HOUSE LTD
DOI: 10.5114/ceji.2020.97911
Keywords
interleukin 39; interleukin 12; B cells; systemic lupus erythematosus; acute coronary; syndrome
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Funding
- National Natural Science Foundation of China [81970735]
- Natural Science Foundation of Zhejiang Province [LY17H010001, LY18H010003]
- K.C. Wong Magna Fund in Ningbo University
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Interleukin (IL)-12 family member is a heterodimer glycoprotein, composed of two covalently linked subunits, alpha and beta chains. The alpha subunit consists of IL-23p19, IL-27p28, and IL-12p35, and the beta subunit includes IL-12p40 and Epstein-Barr virus-induced gene (Ebi3). IL-39 is a new heterodimeric IL-12 family member composed of IL-23p19 and Ebi3 subunits. IL-39 is secreted by lipopolysaccharide-stimulated B cells. Other immune cells, such as dendritic cells and macrophages, express IL-39 mRNA. In lupus-like mice, GL7(+)B cells and CD138(+)plasma cells are highly activated and widely expressed, promoting high expression of IL-39. IL-39 mediates inflammatory responses through binding to a heterodimer of IL-23R/gp130 receptor and activation of signal transducer and activator of transcription (STAT)1/STAT3 signal molecules. The serum levels of IL-39 were significantly increased in patients with acute coronary syndrome compared with patients with normal coronary arteries. This review discusses the biological characteristics, receptor, and signal pathway as well as biological activity of IL-39 and its potential role in inflammation and other diseases.
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