Journal
CURRENT MEDICINAL CHEMISTRY
Volume 22, Issue 6, Pages 713-729Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867322666141212120926
Keywords
Immune-related diseases; immune system; P2X7R antagonists
Funding
- Fondation Norbert Segard (FNS)
- Ecole des Hautes Etudes d'Ingenieur (HEI)
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The purinergic receptor P2X7 is highly expressed in immune peripheral and central cells suggesting its important role in numerous diseases characterized by inflammatory processes like cancer, or neurodegenerative pathologies in relation with modulation of the immune system. Thereby, antagonization of this receptor may be a hopeful therapeutic strategy to treat a large range of diseases. Indeed, selective P2X7 antagonists display beneficial anti-inflammatory, analgesic, and in some cases, anticancer properties. This article will review the involvement of P2X7 in the immune system, the update of P2X7 antagonists series since 2009 and their promising therapeutic potential for the treatment of several immune-related diseases.
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