Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 50, Issue 2, Pages 127-134Publisher
ELSEVIER
DOI: 10.1016/j.ijantimicag.2017.03.012
Keywords
Carbapenem-resistant Enterobacteriaceae; Antimicrobial resistance; Community-associated infections
Funding
- National Institutes of Health T32 'Training in interdisciplinary research to prevent infections (TIRI)' [5T32NR013454-04]
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Carbapenem antibiotics are used as a last resort to treat serious Gram-negative bacteria (GNB) infections; however, carbapenemase-producing strains of GNB have emerged as a major source of resistance. Owing to the highly transmissible nature of plasmid-borne carbapenemases, numerous reports have warned about the likely spread into the community from healthcare settings. Since the prevalence of carbapenem-resistant Enterobacteriaceae (CRE) in the community is largely unknown, we conducted a scoping review of the literature to assess the percentage of CRE isolates that could be associated with the community. Initially, 361 studies were assessed and 15 met the inclusion criteria. Although 5 studies (33.3%) found no community-associated CRE, the remaining 10 studies identified percentages ranging from 0.04% to 29.5% of either community-associated or community-onset CRE among their samples, with US-based studies alone ranging from 5.6 to 10.8%. The presence of CRE in the community poses an urgent public health threat. (C) 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
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