Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 50, Issue 3, Pages 406-412Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijantimicag.2017.04.025
Keywords
Hyperbaric oxygen therapy; Host response; Biofilm; Hypoxia; Neutrophils; Oxidative stress
Funding
- Danish Heart Association (Hjerteforcningen)
- Helene and Georg Jensens Foundation [15-R99-A5982]
- Ethel Merethe and Christian Pontoppidans Foundation [15-R99-A5982]
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Staphylococcus aureus infective endocarditis (IE) is a serious disease with an in-hospital mortality of up to 40%. Improvements in the effects of antibiotics and host responses could potentially benefit outcomes. Hyperbaric oxygen therapy (HBOT) represents an adjunctive therapeutic option. In this study, the efficacy of HBOT in combination with tobramycin in S. aureus IE was evaluated. A rat model of S. aureus IE mimicking the bacterial load in humans was used. Infected rats treated subcutaneously with tobramycin were randomised into two groups: (i) HBOT twice daily (II 13): or (ii) normobaric air breathing (nonHBOT) (n= 17). Quantitative bacteriology, cytokine expression, valve vegetation size and clinical status were assessed 4 days post-infection. Adjunctive HBOT reduced the bacterial load in the aortic valves, myocardium and spleen compared with the non-HBOT group (P = 0.004,
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