Journal
NEW MICROBES AND NEW INFECTIONS
Volume 37, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nmni.2020.100732
Keywords
COVID-19; Encephalitis; Meningitis; Nervous system; Recurrence
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Coronavirus disease 2019 (COVID-19) infection can involve many organs, such as central nervous system, including in relapse. We describe the case of a 64-year-old woman with microbiologically confirmed COVID-19-induced respiratory distress whose treatment resulted in a negative nasopharyngeal swab reverse transcriptase PCR (RT-PCR) result for COVID-19. However, after a few weeks, relapse occurred, as indicated by symptoms of acute meningoencephalitis. Results of COVID-19 RT-PCR testing from her cerebrospinal fluid, nasopharyngeal and tracheal aspiration specimens became positive again, but COVID-19 serum antibodies were negative. We therefore note that symptoms with neurologic involvement can be one of COVID-19's first presentations, or they can appear at relapse. Regular evaluation of patients during convalescence is therefore necessary. (C) 2020 Published by Elsevier Ltd.
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