Journal
VIEW
Volume 1, Issue 3, Pages -Publisher
WILEY
DOI: 10.1002/VIW.20200034
Keywords
cancer; CTCs detection; digital holography artificial intelligence; label-free; liquid biopsy; microfluidics; Quantitative Phase-Contrast Imaging
Funding
- Project PRIN 2017 - Morphological Biomarkers for early diagnosis in Oncology (MORFEO) [2017N7R2CJ]
- MIURPON Project 2014-2020 PROSCAN
- Fondazione Umberto Veronesi
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Circulating tumor cells (CTCs) are rare tumor cells released from primary, metastatic, or recurrent tumors in the peripheral blood of cancer patients. CTCs isolation from peripheral blood and their molecular characterization represent a new marker in cancer screening, a diagnostic tool called liquid biopsy (LB). Compared to traditional tissue biopsy that is invasive and does not reveal tumor heterogeneity, LB is noninvasive and reflects in real-time tumor dynamism and drug sensitivity. In the frame of LB, a new paradigm based on single-cell and label-free analysis based on morphological analysis is emerging. Here, we review the latest research developments in this emerging vision of LB. In particular, we survey and discuss recent improvements in microfluidics, imaging label-free diagnosis and cell classification by artificial intelligence and how to combine them to realize an intelligent platform based on lab-on-chip technology. This prospect appears to open up promising and intriguing new scenarios for cancer management through single-cell analysis that will revolutionize the future of early cancer diagnosis and therapeutic choice with disruptive impact on the society.
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