Journal
SIGNAL TRANSDUCTION AND TARGETED THERAPY
Volume 5, Issue 1, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41392-020-00222-7
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Funding
- National Key Research and Development Program of China [2018YFA0800802]
- National Natural Science Foundation of China [81530071, 81772306, 81721001, 81991513]
- Innovative Research Team in University [IRT1216]
- Key research and development projects of science and technology innovation of social undertakings and people's livelihood security in Chongqing [cstc2017shms-zdyfX0027]
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Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD). In this context, the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.
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