Journal
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volume 47, Issue 13, Pages 857-866Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2017.04.005
Keywords
Kinome; Gene curation; Nematodes; Kinase signalling; Host-parasite interactions
Categories
Funding
- Wellcome Trust, UK
- Australian Academy of Science - Australia
- Australian-American Fulbright Commission - Australia
- Alexander von Humboldt Foundation (Germany)
- Melbourne Water Corporation (Australia)
- Victorian Life Sciences Computation Initiative (VLSCI), Australia
- WormBase
- Melbourne International Fee Remission Scholarship (MIFRS) from the University of Melbourne, Australia
- Melbourne International Research Scholarship (MIRS) from the University of Melbourne, Australia
- National Health and Medical Research Council of Australia (NHMRC)
- Australian Research Council (ARC), Australia
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Roundworms belong to a diverse phylum (Nematoda) which is comprised of many parasitic species including whipworms (genus Trichuris). These worms have adapted to a biological niche within the host and exhibit unique morphological characteristics compared with other nematodes. Although these adaptations are known, the underlying molecular mechanisms remain elusive. The availability of genomes and transcriptomes of some whipworms now enables detailed studies of their molecular biology. Here, we defined and curated the full complement of an important class of enzymes, the protein kinases (kinomes) of two species of Trichuris, using an advanced and integrated bioinformatic pipeline. We investigated the transcription of Trichuris suis kinase genes across developmental stages, sexes and tissues, and reveal that selectively transcribed genes can be linked to central roles in developmental and reproductive processes. We also classified and functionally annotated the curated kinomes by integrating evidence from structural modelling and pathway analyses, and compared them with other curated kinomes of phylogenetically diverse nematode species. Our findings suggest unique adaptations in signalling processes governing worm morphology and biology, and provide an important resource that should facilitate experimental investigations of kinases and the biology of signalling pathways in nematodes. (C) 2017 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.
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