Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 42, Issue -, Pages 150-156Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2016.11.013
Keywords
Deubiquitinating enzymes; E3 ubiquitin ligases; T helper cell differentiation
Categories
Funding
- National Natural Science Foundation of China [31371427, 31601131]
- Ministry of Education of China [201427]
- State Key Laboratory of Veterinary Etiological Biology [SKLVEB2015KFKT001]
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CD4 T cells are essential components of adaptive immunity and play a critical role in anti-pathogenic or antitumor responses as well as autoimmune and allergic diseases. Naive CD4 T cells differentiate into distinct subsets of T helper (Th) cells by various signals including TCR, costimulatory and cytokine signals. Accumulating evidence suggests that these signaling pathways are critically regulated by ubiquitination and deubiquitination, two reversible posttranslational modifications mediated by E3 ubiquitin ligases and deubiquitinating enzymes (DUBs), respectively. In this review, we briefly introduce the signaling pathways that control the differentiation of Th cells and then focused on the roles of E3s- and DUBs-mediated ubiquitin modification or demodification in regulating Th cell differentiation. (C) 2016 Elsevier B.V. All rights reserved.
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