Journal
INTERNATIONAL IMMUNOLOGY
Volume 29, Issue 4, Pages 149-155Publisher
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxx015
Keywords
inflammatory cytokine; mRNA stability; RNA-binding protein; zinc-finger protein
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Funding
- Japan Society for the Promotion of Science (JSPS) [15H05704]
- National Institutes of Health [5P01AI070167]
- [26460580]
- Grants-in-Aid for Scientific Research [15H05704] Funding Source: KAKEN
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Current studies using knockout mice have revealed that some Cys-Cys-Cys-His (CCCH)-type zinc-finger proteins, namely tristetraprolin (TTP), Roquin and Regnase-1, play important roles in the immune system. These proteins are closely associated with the fate of their target RNAs in normal immune responses. However, the functions of many RNA-binding proteins have not been characterized precisely. To understand the molecular mechanisms of RNA metabolism in the immune system, investigation of TTP/Roquin/Regnase-1 might provide new knowledge. In this review, we will discuss the current understanding of these proteins in immune regulation and homeostasis and discuss RNA metabolism in the immune system.
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