Journal
REACTION CHEMISTRY & ENGINEERING
Volume 5, Issue 9, Pages 1751-1758Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0re00191k
Keywords
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Funding
- Novartis-MIT Center for Continuous Manufacturing
- National Natural Science Foundation of China [21978146, 21991103]
- Tsinghua University Initiative Scientific Research Program [2019Z08QCX02]
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An automated flow platform based on a tube-in-tube contactor and micro-packed bed reactor is developed to measure the kinetics of gas-liquid-solid hydrogenation reactions. The liquid flowing in the inner tube of the tube-in-tube contactor is rapidly saturated to ensure a constant H(2)concentration before entering the micro-packed bed, which transforms the gas-liquid-solid system into a liquid-solid system. A ramping strategy is adopted in which the continuously varied residence time and the corresponding conversion data are obtained in a single experiment. Two reactions including hydrogenation of alpha-methylstyrene and nitrobenzene are chosen to demonstrate the accuracy and efficiency of this automated platform. Varying the flow rate ramping shows that accurate kinetic determination requires a specific range of flow rate ramps. A kinetic curve of conversionversusresidence time (more than ten thousand data points) can be obtained in a single experiment within 50 min. The kinetic parameters obtained with this strategy agree well with literature values. The automated flow platform with flow rate ramping enables accurate determination of gas-liquid-solid reaction kinetics with higher efficiency and lower reagent cost compared with other methods.
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