Journal
APPLIED SURFACE SCIENCE
Volume 530, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.apsusc.2020.147197
Keywords
Layer-by-layer; Polyvinylamine; Dopamine-modified hyaluronic acid; Antimicrobial coatings; Biocompatibility
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Funding
- National Natural Science Foundation of China [21805229, 51878555]
- Fundamental Research Funds for the Central Universities [3102017OQD039, 3102019smxy003, 3102019ghxm017]
- Shaanxi International Cooperation Foundation [2017KW-41]
- Shaanxi Funding Scheme to Outstanding Scientific and Technological Programs by Returned Overseas Chinese Scholars [2018029]
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Layer-by-layer (LbL) assembly technique has been proven to be a convenient and eco-friendly method to obtain multifunctional coatings. In this research we presented a hydrophilic and transparent coating on various types of substrates by layer-by-layer deposition of polyvinylamine (PVAm) and dopamine-modified hyaluronic acid (HA-DN). The successfully constructed multilayers on gold surface were monitored by quartz crystal microbalance (QCM). The coating significantly improved the hydrophilicity of glass, stainless steel, gold, and polyvinyl chloride (PVC) surface as compared with the unmodified ones, which can reduce the water contact angle of the substrates by 30% to 45%. The growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) was significantly inhibited on LbL-coated PVC, and 6 bilayers of coating can achieve nearly 100% suppression of bacterial growth. The coating was with no toxicity to mouse lymphocytes in polystyrene (PS) cell culture plate, while it significantly attenuated the viability of Michigan cancer foundation - 7 cells (MCF7) and human acute monocytic leukemia cell line (THP-1) in vitro. Therefore, this hydrophilic, transparent, antibacterial, biocompatible, and tumor-cell-suppressive coating would have broad potential in biomedical applications.
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