Journal
RSC ADVANCES
Volume 10, Issue 28, Pages 16727-16731Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ra03291c
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We developed conjugates between monoclonal antibody (mAb) and folic acid (FA) by using a tryptophan (Trp)-selective reaction, which yields relatively homogenous products compared to conventional methods. The obtained mAb-FA conjugates showed significant cellular cytotoxicity toward folate receptor-expressing cancer cells, demonstrating that the conjugates retained the Fc region's original function.
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