Journal
FEMS MICROBIOLOGY REVIEWS
Volume 44, Issue 3, Pages 305-313Publisher
OXFORD UNIV PRESS
DOI: 10.1093/femsre/fuaa007
Keywords
Anellome; Anelloviridae; anellovirus; commensal virus; orphan virus; torque teno virus
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Funding
- European Union's Horizon 2020 research and innovation programme, under the Marie Sklodowska-Curie Actions [721367]
- Amsterdam UMC
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Anelloviruses are small, single stranded circular DNA viruses. They are extremely diverse and have not been associated with any disease so far. Strikingly, these small entities infect most probably the complete human population, and there are no convincing examples demonstrating viral clearance from infected individuals. The main transmission could be via fecal-oral or airway route, as infections occur at an early age. However, due to the lack of an appropriate culture system, the virus-host interactions remain enigmatic. Anelloviruses are obviously mysterious viruses, and their impact on human life is not yet known, but, with no evidence of a disease association, a potential beneficial effect on human health should also be investigated.
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