Journal
INTERNAL MEDICINE JOURNAL
Volume 47, Issue 9, Pages 1064-1067Publisher
WILEY
DOI: 10.1111/imj.13533
Keywords
computed tomography; kidney stone; osteoporosis; thalassaemia; urolithiasis
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Funding
- Australian Postgraduate Scholarship
- Royal Australasian College of Physicians and Osteoporosis Australia Scholarship
- National Health and Medical Research Council (Australia) CJ Martin Early Career Fellowship
- Haematology Society of Australia
- Haematology Society of New Zealand
- National Health and Medical Research Council (Australia) Senior Principal Research Fellowship [1002559]
- Victorian Government's Operational Infrastructure Support program
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Asymptomatic urolithiasis is common and of mixed composition in patients with beta-thalassaemia major. Twenty-seven subjects were imaged using dual-energy computer tomography to determine the presence and composition of urolithiasis. The prevalence of urolithiasis was 59% and affected patients generally had multiple stones, often with more than one component: struvite (33%), calcium oxalate (31%) and cystine (22%). Hypercalciuria was present in 78% of subjects and calcium-containing urolithiasis was associated with reduced femoral neck Z scores.
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