Journal
INTEGRATION-THE VLSI JOURNAL
Volume 58, Issue -, Pages 446-453Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vlsi.2017.03.005
Keywords
Nanosecond pulsed electric field; Single and multi-cell electroporation; Microfluidics; High voltage
Funding
- Joint IIT-Sapienza LAB on Life-NanoScience Project [81/13 16-04-2013]
- National Grant Research Projects of Sapienza University of Rome [C26A15T3T2]
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The emergence of nanosecond pulsed electric fields (nsPEFs) for intracellular manipulation experiments requires the use of specific miniaturized applicators. We propose the design of a versatile nsPEFs applicator, based on microwave propagating systems, suitable for in vitro exposure to undistorted 1-3 ns pulses in single and multi-cell experiments. Further features of the proposed devices are: high efficiency, microfluidic integration, real time monitoring of the biological sample and of the pulse propagation. Generally, these features can be considered as specific requisites for nanosecond applicators, to ensure experimental repeatability and reproducibility, when propagation related phenomena cannot be considered negligible.
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