Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 25, Issue -, Pages 1-42Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/4793
Keywords
microRNAs; endo-siRNAs; Argonaute; mammals; In Vivo; Review
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Funding
- Intramural Research Program of the National Institutes of Health (NIH)
- FLEX grant from the Center for Cancer Research (CCR)
- NATIONAL CANCER INSTITUTE [ZIABC011810] Funding Source: NIH RePORTER
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Argonaute (AGO) proteins play key roles in animal physiology by binding to small RNAs and regulating the expression of their targets. In mammals, they do so through two distinct pathways: the miRNA pathway represses genes through a multiprotein complex that promotes both decay and translational repression; the siRNA pathway represses transcripts through direct Ago2-mediated cleavage. Here, we review our current knowledge of mechanistic details and physiological requirements of both these pathways and briefly discuss their implications to human disease.
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