Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 69, Pages 10038-10041Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc04348f
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Funding
- National Natural Science Foundation of China [21635008, 21874140, 21535009, 21705153]
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Herein, we report a FnCas12a/crRNA assisted Dumbbell-PCR method for the detection of isomiRs with double specificity and magnification. The single nucleotide variant of isomiRs in terminals and/or inner sequence could be discriminated by this strategy. Using this method, let-7a isomiRs in MCF-7 and MCF-7R cell lines were analyzed.
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