Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 69, Pages 10018-10021Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc04424e
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Funding
- National Natural Science Foundation of China [21722206, 21672171]
- Natural Science Basic Research Program of Shaanxi [2020JQ-993]
- Shaanxi Government
- Scientific Research Foundation of Northwest AF University [Z109021709, Z111021501, Z109021600]
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Herein, we developed an enantioselective addition of aliphatic aldehydes to 2-hydroxychalcone promoted by cooperative organocatalysts, giving access to hybrid flavonoids in excellent enantioselectivities. This reaction took advantage of cycloisomerization of 2-hydroxychalcone to form a transient flavylium under the irradiation of 24 W CFL, which was trapped by thein situgenerated chiral enamine intermediate. The synergistic action of chiral phosphoric acid secured the excellent outcome of this reaction by ion-pairing with the transient flavylium.
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