Journal
NATURAL PRODUCTS AND BIOPROSPECTING
Volume 10, Issue 5, Pages 307-316Publisher
SPRINGERNATURE
DOI: 10.1007/s13659-020-00259-9
Keywords
Lamiaceae; Essential oil; Chemical composition; Cytotoxicity; Anti-inflammatory activity; Neglected diseases
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Funding
- Al-Balqa' Applied University, Al-Salt, Jordan, at the National Center for Natural Products Research, School of Pharmacy, University of Mississippi, USA
- Foundation for Science and Technology (FCT), Portugal [UID/NEU/04539/2013, UID/NEU/04539/2019, UIDB/04539/2020, UIDP/04539/2020]
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In Jordan,Salvia ceratophyllaL. is traditionally used in the treatment of cancer, microbial infections, and urinary disorders. This study aimed: (1) to chemically characterizeS. ceratophyllaessential oil (EO) from South Jordan, by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS); and (2) to evaluate in vitro the cytotoxic, anti-inflammatory, and antiprotozoal activities of the EO, it's predominant components, and the hexane (A), ethyl acetate (B), methanol (C) and crude-methanol extracts (D). The analysis revealed that the EO has 71 compounds, with linalool (54.8%) as main constituent. Only the hexane extract (A) showed some cytotoxic activity against SK-MEL, KB, BT-549, SK-OV-3, LLC-PK1 and VERO cells lines with IC(50)between 60 and > 100 mu g/mL. The EO inhibited NO production (IC(50)90 mu g/mL) and NF-kappa B activity (IC(50)38 mu g/mL). The extracts A, B, and D inhibited NO production and NF- kappa B activity with IC(50)between 32 and 150 mu g/mL. Linalool considerably inhibited NO production (IC(50)18 mu g/mL). The extracts tested did not exhibit antileishmanial activity. Regarding antitrypanosomal activity, the EO exhibited significant results with IC(50)2.65 mu g/mL. In conclusion, JordanS. ceratophyllaEO represents a rich source of linalool and bears a promising therapeutic potential for further antitrypanosomal drug development.
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