Journal
INORGANIC CHEMISTRY COMMUNICATIONS
Volume 84, Issue -, Pages 144-149Publisher
ELSEVIER
DOI: 10.1016/j.inoche.2017.08.013
Keywords
Acyclic Schiff base; Bovine serum albumin; Molecular docking; Cleavage studies
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Mononuclear copper(II) (1) and nickel(II) complexes (2) of acyclic Schiff base ligand, N,N'-bis(2-hydroxy-1naphthyl)-1,4-bis(3-iminopropyl) piperazine (L) were synthesized and characterized. The molecular structure of the ligand was confirmed using single crystal X-ray diffraction analysis. The complexes displayed good binding abilities to bovine serum albumin protein (BSA). The binding interactions of complexes 1 and 2 with calf thymus DNA (CT-DNA) was investigated by absorption, fluorescence, circular dichroism spectral analysis and molecular docking studies. Complex 1 showed greater interaction with DNA than nickel(II) complex 2. The cleavage studies with pBR322 DNA showed efficient oxidative cleavage in the presence of 3-mercaptopropionicacid (MPA) and for hydrogen peroxide for complexes 1 and 2 respectively. (C) 2017 Elsevier B.V. All rights reserved.
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