Journal
INORGANIC CHEMISTRY
Volume 56, Issue 14, Pages 8128-8134Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.inorgchem.7b00845
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Funding
- National Natural Science Foundation
- Ministry of Science and Technology of the People's Republic of China [NSFC21671162, NSFC21471126, 2016YFA0200702]
- National Thousand Talents Program of the People's Republic of China
- 985 Program of Chemistry and Chemical Engineering Disciplines of Xiamen University
- U.S. National Science Foundation [DMR-1308229]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1308229] Funding Source: National Science Foundation
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Nanoscale metal organic frameworks (nMOFs) have shown tremendous potential in cancer therapy and biomedical imaging. However, their small dimensions present a significant challenge in structure determination by single-crystal X-ray crystallography. We report here the structural determination of nMOFs by rotation electron diffraction (RED). Two isostructural Zr- and Hf-based nMOFs with linear biphenyldicarboxylate (BPDC) or bipyridinedicarboxylate (BPYDC) linkers are stable under intense electron beams to allow the collection of high-quality RED data, which reveal a MOF structure with M-12(mu(3)-O)(8)(mu(3)-OH)(8)(mu(2)-OH)(6) (M = Zr, Hf) secondary building units (SBUs). The nMOF structures differ significantly from their UiO bulk counterparts with M-6(mu(3)-O)(4)(mu(3)-OH)(4) SBUs and provide the foundation for clarifying the structures of a series of previously reported nMOFs with significant potential in cancer therapy and biological imaging. Our work clearly demonstrates the power of RED in determining nMOF structures and elucidating the formation mechanism of distinct nMOF morphologies.
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