Journal
INORGANIC CHEMISTRY
Volume 56, Issue 18, Pages 11176-11183Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.inorgchem.7b01549
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21571142]
- Developing Science Funds of Tongji University and Science & Technology Commission of Shanghai Municipality [14DZ2261100]
Ask authors/readers for more resources
A luminescent nanoprobe based on a lanthanide-transition heterometallic metal-organic framework (MOF) is first designed for specific detection of urinary thiodiglycolic acid (TDGA) which is the biomarker of carcinogenic vinyl chloride monomer (VCM) and represents the internal dose of human exposure to VCM. The nanoprobe demonstrates high selectivity to TDGA with about 27.5-fold luminescence enhancement. It also displays excellent sensitivity with a detection limit as low as 89 ngmL(-1) and fast response to TDGA within 4 min, while refraining from the interference of other coexisting species in urine. Such good sensing performance enables the nanoprobe to practically monitor TDGA levels in human urine. Moreover, a portable urine dipstick based on the sensor is developed to conveniently evaluate individuals' intoxication degree of VCM. This fast, sensitive, and selective nanoprobe has promising potential to be a useful tool for point-of-care diagnosis of disease associated with VCM exposure.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available